Česky
English
Výbor pro spolupráci ČR se Spojeným ústavem jaderných výzkumů Dubna Přihlášení
Formation of Direct and Enzymatic DNA Double-Strand Breaks in the Presence of Repair Inhibitors after Exposure to Radiations of Different Quality

Autor
Chausov V.N. SÚJV
Ježková  Lucie, Ing., Ph.D. Vysoká škola chemicko-technologická v Praze
et al.  různé instituce

Rok
2018

Časopis
Physics of Particles and Nuclei Letters, 15 (6), 700-710

Web


Obsah
With the use of the DNA comet assay and immunocytochemical staining, regularities have been studied in the induction and repair of DNA double-strand breaks(DSBs) in human cells after exposure to Co-60 -rays and accelerated heavy ions with different linear energy transfer (LET) in the presence of the DNA repair inhibitors cytosine arabinoside and hydroxyurea. It is shown that for heavy ions the agents' modifying effect decreases with increasing particles' LET. The approach involving DNA synthesis inhibitors used in this study allows an estimation of the proportion of enzymatic DNA DSBs in total DSB yield after exposure to ionizing radiations of different quality.

Příklad citace článku:
V. Chausov, L. Ježková , . et al., "Formation of Direct and Enzymatic DNA Double-Strand Breaks in the Presence of Repair Inhibitors after Exposure to Radiations of Different Quality", Physics of Particles and Nuclei Letters, 15 (6), 700-710 (2018)