Česky
English
Committee for collaboration of Czech Republic

with Joint Institute for Nuclear Research in Dubna Login
The Influence of Physical Characteristics of Accelerated Heavy Ions on the Formation and Repair of DNA Double-Strand Breaks

Author
Boreyko  A. JINR
Bulanova T.S. JINR
Ježková  Lucie, Ing., Ph.D.
Krasavin E.A. JINR
et al.  different institutions

Year
2018

Scientific journal
Physics of Particles and Nuclei Letters, 15 (6) 693–699

Web


Abstract
The kinetics of formation and elimination of H2AX/53B?1 foci induced by accelerated B-11, Ne-20, and N-15 ions with different physical characteristics in human skin fibroblasts have been investigated. The results of the elimination kinetics for radiation-induced H2AX/53BP1 foci (RIF) reveal that a decrease in the energy and an increase of the linear energy transfer (LET) of the particles reduce the efficiency of doublestrand break (DSB) repair. An investigation into the structure of RIF induced by accelerated Ne-20 and B-11 ions with various physical parameters shows significant differences in the nature of the RIF that is formed. It is found that Ne-20 ions with a high density of rays in tracks (Z*(2)/(2) = 1454) induce larger clustered H2AX/53BP1 foci with a more complex structure than B-11 ions with a lower density of rays in tracks (Z*(2)/(2) = 494), which indicates the formation of more severe complex damage to genetic structures, first and foremost, DNA DSBs.

Cite article as:
A. Boreyko , T. Bulanova, L. Ježková , E. Krasavin, . et al., "The Influence of Physical Characteristics of Accelerated Heavy Ions on the Formation and Repair of DNA Double-Strand Breaks ", Physics of Particles and Nuclei Letters, 15 (6) 693–699 (2018)